Natural source, bioactivity and synthesis of 3-Arylcoumarin derivatives

Abstract

3-arylcoumarins with different pharmacological properties widely exist in a variety of natural plants. The extensive research on 3-arylcoumarins was attributed to its therapeutic and relatively easy isolation. Therefore, 3-arylcoumarins can be recognised as useful structures for the design of novel compounds with potential pharmacological interest, particularly in the fields of anti-inflammatory, anti-cancer, antioxidant, Monoamine oxidase (MAO) enzyme inhibition, etc. The current review highlights the biological activities, design, and chemical synthetic methods of 3-arylcoumarins derivatives as well as their important natural product sources.

Keywords:

• Natural product sources
• 3-arylcoumarin derivatives
• bioactivity
• synthesis

Disclosure statement

The authors declare that the content in this review has no conflict of interest.

Additional information

Funding

This work was financially supported by Shandong Provincial Natural Science Foundation [ZR2020kH020]. and the academic promotion program of Shandong First Medical University (nos.2019LJ003).