Arctigenin: pharmacology, total synthesis, and progress in structure modification

Abstract

Arctium lappa L. is a prevalent medicinal herb and a health supplement that is commonly used in Asia. Over the last few decades, the bioactive component arctigenin has attracted the attention of researchers because of its anti-inflammatory, antioxidant, immunomodulatory, multiple sclerosis fighting, antitumor, and anti-leukemia properties. After summarising the research and literature on arctigenin, this study outlines the current status of research on pharmacological activity, total synthesis, and structural modification of arctigenin. The purpose of this study is to assist academics in obtaining a more comprehensive understanding of the research progress on arctigenin and to provide constructive suggestions for further investigation of this useful molecule.

Keywords:

• Arctigenin
• pharmacology
• total synthesis
• structure modification

Acknowledgements

The authors gratefully acknowledge the National Natural Science Foundation of China.

Disclosure statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Additional information

Funding

This work was supported by the National Natural Science Foundation of China [No.81960626, 82160741, 82160666, 82060628], Doctoral Research Start-up Fundation of Yanbian University [No. ydbq202215] and Jilin Provincial Education Department of China [JJKH 20191156KJ].