Research progress of natural products and their derivatives against Alzheimer’s disease

Abstract

Alzheimer’s disease (AD), a persistent neurological dysfunction, has an increasing prevalence with the aging of the world and seriously threatens the health of the elderly. Although there is currently no effective treatment for AD, researchers have not given up, and are committed to exploring the pathogenesis of AD and possible therapeutic drugs. Natural products have attracted considerable attention owing to their unique advantages. One molecule can interact with multiple AD-related targets, thus having the potential to be developed in a multi-target drug. In addition, they are amenable to structural modifications to increase interaction and decrease toxicity. Therefore, natural products and their derivatives that ameliorate pathological changes in AD should be intensively and extensively studied. This review mainly presents research on natural products and their derivatives for the treatment of AD.

Keywords:

• Natural product
• Alzheimer’s disease
• cholinease inhibitor

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was financially supported by the Higher Education Discipline Innovation Project (111 Project, D18012), National Natural Science Foundation of China [No. 81960626, 82060628, 82204310, 82260002, 81460001], Natural Science Research Foundation of Jilin Province for Sciences and Technology [No. 20220101353JC], Education Department Project of Jilin [No. JJKH20220563KJ, JJKH20220546KJ]. Doctoral Research Start-up Fundation of Yanbian University [No. ydbq202215, ydbq202217].