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Abstract
Type 2 diabetes (T2D) is a progressive metabolic disorder of glucose metabolism. One of the therapeutic approaches for the treatment of T2D is reducing postprandial hyperglycaemia through inhibition of the digestive enzymes α-glucosidase and α-amylase. In this context, aimed at identifying natural products endowed with anti-T2D potential, we focused on Ptilostemon casabonae (L.) Greuter, a species belonging to Asteraceae family. Enzymatic inhibition, antioxidant activity, phenolic composition and cellular assays were performed. This study revealed that the P. casabonae hydroalcoholic extract exerts a potent inhibitory activity against α-glucosidase. This activity is supported by an antioxidant effect, preventing ROS formation in a stressed cellular system. HPLC-PDA-MS/MS analysis, revealed a complex polyphenolic fraction. Among the tested pure compounds, 1,5-dicaffeoylquinic acid, apigenin and rutin displayed good α-glucosidase inhibitory activity. Our study suggested new potential of P. casabonae encouraging us to further testing the possible therapeutic potential of this extract.
Graphical Abstract
Author contributions
Conceptualisation, C.S. and F.P.; methodology, C.S., A.F., A.M., P.R., S.F. and F.P.; investigation, C.S., B.E., A.R., A.M., P.R., A.D.A., S.F. and F.P.; writing—original draft preparation, C.S., S.F. and F.P.; writing—review and editing, A.F., B.E., G.L.D., E.S., L.D. and A.R.; funding acquisition, C.S., A.F., G.L.D., E.S., L.D. and F.P. All authors have read and agreed to the published version of the manuscript.
Disclosure statement
No potential conflict of interest was reported by the author(s).