The safety and efficacy of insulin analogs in pregnancy

Abstract

Diabetesduring pregnancy isaccompanied by increasing needsfor maternal insulin and ongoing biological changes that cause maternal insulin requirements to reach higher and lower extremes throughout the day than in non-pregnant patients. As maternal hyperglycemia increases the risk of fetal and maternal morbidity, it is essential for the mother to maintain normoglycemia during pregnancy. With the advent of insulin analogs that feature improved absorption and physiological profilesover human insulin, the achievement of normoglycemia throughout pregnancy hasbecome more attainable. This review provides a discussion of the application of the insulin analogs to diabetesduring pregnancy and comparesthe benefitsof rapid-acting insulin analogswith longacting insulin analogsduring pregnancy. Thisreview further proposesa treatment protocol for achieving and maintaining normoglycemia throughout pregnancy.

• Diabetes
• Pregnancy
• Insulin Analogs
• Insulin
• Macrosomia
• Gestational Diabetes