Prolonged morphine exposure in utero causes fetal and placental vasoconstriction: A case report

Laura R Collins Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USACorrespondence[email protected]

Richard W Hall Department of Neonatology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

Nafisa K Dajani Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

Paul J Wendel Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

Curtis L Lowery Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

Helen H Kay Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

Abstract

Vasoconstriction was observed in the fetal middle cerebral and umbilical arteries by Doppler assessment at 27 weeks gestation in a patient requiring continuous morphine infusion for pain control. Fetal heart tracings were also concerning. Fetal status improved after a change to fentanyl infusion, a shorter acting opioid. Caution is recommended when long-term chronic narcotic infusion is used in pregnancy.

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Prolonged morphine exposure in utero causes fetal and placental vasoconstriction: A case report

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Prolonged morphine exposure in utero causes fetal and placental vasoconstriction: A case report

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