E2. Preeclampsia is associated with persistent arterial stiffness into the postpartum period despite recovery of the vasoconstrictive state

Abstract

Introduction: Preeclampsia is associated with vascular dysfunction and long-term cardiovascular disease. A novel technique, TensioMed measuring Pulse Wave Velocity (PWV) and Augmentation index (Aix) to estimate arterial stiffness and vasoconstriction respectively during pregnancy and 6 months postpartum.

Targets: Our aim was to evaluate vascular function during pregnancy and the postpartum period in women with preeclampsia compared to uncomplicated pregnancy. We evaluated 11 preeclampsia women, diagnosed with hypertension (4140/90 mmHg) and proteinuria (spot urine protein/creatine ratio 430 mg/mmol) and 7 women with uncomplicated pregnancy. Vascular function (AIx and PWV) was assessed using TensioMed. The data were analysed using repeated measures two-way ANOVA.

Results: There was a significantly higher PWV in women with preeclampsia during pregnancy and postpartum (p = 0.0068). Incontrast, AIx were abnormally higher during pregnancy in the preeclampsia group and improved postpartum. AIx in control group was within normal limits during pregnancy and increased postpartum (Interaction p = 0.0004).

Conclusions: Our data suggest that preeclampsia is associated with persistent arterial stiffness into the postpartum period despite recovery of the vasoconstrictive state.