Role of mean platelet volume and ischemia modified albumin in evaluation of oxidative stress and its association with postnatal complications in infants of diabetic mothers

Abstract

Gestational diabetes mellitus (GDM) is accompanied by increased oxidative stress, causing many complications to pregnant women and their newborns. We aimed to determine cord blood levels of mean platelet volume (MPV) and ischemia modified albumin (IMA) as a reflection of oxidative stress in babies born to mothers suffering from GDM. Eighty pregnant women were enrolled in the study. They were divided into two groups: 40 with GDM and 40 healthy matched controls. Each group included twenty giving birth by normal vaginal delivery (NVD) and twenty by cesarean section (C.S). The MPV and the IMA levels were measured. Complete physical examination of babies was done at birth and follow up at age of one week. Comparison between infants of diabetic mothers and of healthy mothers showed statistically significant difference in the levels of MPV (p < .001) and IMA (p = .001). Also, there was a statistically significant difference in MPV (p < .001) and IMA (p = .005) between diabetic females who gave birth by NVD and C.S. ROC curve analysis showed that IMA and MPV variables were related to the postnatal outcomes. MPV and IMA are useful markers of the potential oxidative stress in infants of diabetic mothers and of postnatal complications.

Keywords:

• Gestational diabetes mellitus (GDM)
• ischemia modified albumin (IMA)
• mean platelet volume (MPV)
• oxidative stress
• postnatal complications

Disclosure statement

All authors have no conflicts of interest to declare. The study received no grant. This manuscript has not been published elsewhere and it has not been submitted simultaneously for publication elsewhere.