Abstract
Objective
To determine the impact of low-dose aspirin (81 mg) on markers of maternal inflammation and placental function.
Setting
Rural Southern India
Population
Nulliparous women with a singleton pregnancy dated by ultrasound who were enrolled in the ASPIRIN (Aspirin Supplementation for Pregnancy Indicated risk Reduction In Nulliparas) Trial.
Methods
We performed a case-control study to elucidate the impact of low dose aspirin (LDA) on markers of placental function and maternal inflammation among women who delivered prematurely compared to term controls in women enrolled in the ASPIRIN trial. Women were prospectively enrolled in an ancillary observational trial wherein maternal serum was collected and measured between 10 to 13 weeks and 17 to 21 weeks of gestation after initiation of aspirin or an identical placebo.
Results
From 2016-18 with a total of 666 n women enrolled in this ancillary trial of whom 269 were selected for analyte analysis. Women who received LDA had lower levels of Alpha Feto-Protein (AFP) at 10 to 13 weeks than women who received placebo (Placebo) (LDA 18.3 ng/mL vs 21.4 ng/mL -P 0.001). AFP was similar between the two groups at 17 to 21 weeks. No other differences were seen in C-Reactive protein or Anti-Mullerian Hormone.
Conclusion
Low-dose aspirin administration lowers AFP early in pregnancy.
Author contributions
RA conceived of the manuscript and wrote the first draft with input from MSS, MKH and SSG. AK, RA, SSV, MSS and SSG oversaw study implementation, data collection and quality monitoring. RA, AK, and MSS performed the statistical analyses. All authors reviewed and approved the final manuscript.
Clinical trial registration
ClinicalTrials.gov, NCT02409680, and the Clinical
Trial Registry-India, CTRI/2016/05/006970.
Reprints: Reprints will not be provided.
Disclosure statement
The authors report no conflict of interest