https://orcid.org/0000-0002-8531-7124
![Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days]({"type":"image" , "src" : "/sda/5944/TOC-Subject-Sample-2021-Medicine-Dentistry-Nursing-Allied-Health.jpg"})
Abstract
Introduction
Placental chronic deciduitis is a lesion consistent with the presence of plasma cells within the placental basal plate. It could be associated with adverse pregnancy outcomes, including stillbirth.
Methods
We retrospectively evaluated a cohort of 180 antepartum stillborn cases from singleton pregnancies, with the aim of investigating the clinical-histopathological relationship. Placental slides were reviewed following the standard protocol proposed by the “Amsterdam consensus statement”.
Results
We observed an association between chronic deciduitis and lesions consistent with maternal vascular malperfusion, delayed villous maturation, villitis of unknown etiology and maternal autoimmunity.
Conclusions
The observed clinical-histopathological associations suggest that an extensive maternal investigation could improve the comprehension of factors interfering with the placental development and the increasing risk of adverse pregnancy outcomes.
Chronic deciduitis is associated with lesions consistent with maternal vascular malperfusion
Chronic deciduitis is associated with delayed villous maturation
Chronic deciduitis is associated with villitis of unknown etiology
Chronic deciduitis is associated with maternal autoimmunity
Highlights
Keywords:
Disclosure statement
The authors declared no conflict of interest.
Author contributions
LA: conception and design, acquisition of data, analysis and interpretation of data, literature search, drafting the manuscript; FM and CS: acquisition of data, literature search, drafting the manuscript; DM: statistical analysis and drafting the manuscript; FF: revising the manuscript critically for important intellectual content; GB: performed histologic evaluation, revising the manuscript critically for important intellectual content, supervision of the research group.