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Review Article

Macrosomia and fetal growth restriction: evidence for similar extrauterine metabolic risks but with differences in pathophysiology

Inga Tsantekidoua School of Medicine, National and Kapodistrian University of Athens, Athens, Greece

Nikolaos Evangelinakisb Reproductive Endocrinology Unit, 3rd Department of Obstetrics and Gynecology, University General Hospital “Attikon”, Medical School, National and Kapodistrian University of Athens Greece, Athens, Greece

Alexandra Bargiotac Department of Endocrinology and Metabolic Disorders, University Hospital of Larissa, Medical School of Larissa, University of Thessaly, Larissa, Greece

Nikolaos Vrachnisb Reproductive Endocrinology Unit, 3rd Department of Obstetrics and Gynecology, University General Hospital “Attikon”, Medical School, National and Kapodistrian University of Athens Greece, Athens, Greece

Sophia Kalantaridoub Reproductive Endocrinology Unit, 3rd Department of Obstetrics and Gynecology, University General Hospital “Attikon”, Medical School, National and Kapodistrian University of Athens Greece, Athens, Greece

Georgios Valsamakisc Department of Endocrinology and Metabolic Disorders, University Hospital of Larissa, Medical School of Larissa, University of Thessaly, Larissa, Greece;d 2nd Department of Obstetrics and Gynecology, University Hospital “Aretaieion”, Medical School, National and Kapodistrian University of Athens Greece, Athens, GreeceCorrespondence[email protected]

Abstract

Purpose

To investigate and compare the causes of macrosomia and FGR fetuses, their ultrasound characteristics and the importance of their similar metabolic profile in intrauterine and extrauterine life.

Materials and methods

We searched Pubmed/Google Scholar database up until 15 December 2020 using keywords. Out of the 70 matching results we selected 50 most representative and matching papers.

Results

We found similar causes and metabolic profiles and in both conditions offspring are at increased risk of developing metabolic and cardiovascular diseases in the extrauterine life.

Conclusion

Despite similarities of the maternal factors and fetal metabolic profile it is still unknown which of them has worse metabolic status during intrauterine and extrauterine life.

Keywords:

Disclosure statement

No potential conflict of interest was reported by the author(s).

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Macrosomia and fetal growth restriction: evidence for similar extrauterine metabolic risks but with differences in pathophysiology

Purpose

Materials and methods

Results

Conclusion

Information for

Open access

Opportunities

Help and information

Macrosomia and fetal growth restriction: evidence for similar extrauterine metabolic risks but with differences in pathophysiology

Abstract

Purpose

Materials and methods

Results

Conclusion

Disclosure statement

Reprints and Corporate Permissions

Academic Permissions

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