Insufficient antenatal identification of fetal growth restriction leading to intrauterine fetal death: a regional population-based study in Japan

Abstract

Objective

Fetal growth restriction (FGR) is associated with perinatal adverse outcomes including intrauterine fetal death. Antenatally unidentified FGR has a higher risk of intrauterine fetal death than that identified antenatally. We, therefore, investigated the antenatal identification of FGR among intrauterine fetal deaths, and assessed the perinatal factors associated with the identification of FGR.

Methods

This retrospective and population-based study reviewed all stillbirths in Shiga Prefecture, Japan, from 2007 to 2016 with exclusion criteria of multiple births, births at unidentified gestational weeks or < 22 gestational weeks, and lethal disorders. We analyzed cases of FGR, using the Japanese clinical definition: Z-score of estimated fetal weight for gestational age <−1.5 standard deviations (SD).

Results

We identified 94 stillbirths with FGR among 429 stillbirths. Thirty-seven cases were antenatally identified during pregnancy management (39%). Dividing cases by a Z-score of −2.5 SD, 51 cases were classified as ≤−2.5 SD. Twenty-eight of the 51 cases (55%) with a Z-score <−2.5 SD were antenatally identified as having FGR, whereas 9 of the 43 cases (21%) with a Z-score ≥−2.5 SD were antenatally identified as having FGR (p = .002). Among cases with a Z-Score <−2.5 SD, 16 of 21 (76%) beyond 28 weeks’ gestation and 12 of 30 (40%) before 28weeks’ gestation were antenatally identified as having FGR (p = .023).

Conclusion

Fetal growth restriction leading to intrauterine fetal death in Japan was antenatally identified in less than half of cases. Antenatal identification of FGR was associated with the severity of growth restriction.

Keywords:

• Antenatal identification
• fetal growth restriction
• intrauterine fetal death
• stillbirth
• population-based study

Acknowledgement

We would like to express our appreciation to the peer-review team members.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This study was supported by JSPS KAKENHI Grant Number JP15K08803.