Abstract
Introduction
The evaluation of upcoming Aortic Coarctation (CoA) in new-borns with prenatal suspicion entails a close echocardiographic monitor until Arterial Duct (AD) closure, in a department with pediatric cardiological and surgical expertise. The significant number of false-positive prenatal diagnoses causes parental stress and healthcare costs.
Aim
The aim of this study was to elaborate an echocardiographic prediction model to be employed at birth when PDA is still present, in patients suspected of CoA during fetal life in order to foretell CoA requiring neonatal surgical intervention.
Methods
This retrospective monocentric study included consecutive full-term and late preterm neonates with prenatal suspicion of CoA born from 01 January 2007 to 31 December 2020. Patients were divided into two groups according to the need for aortic surgery (CoA - NoCoA). All patients underwent a comprehensive transthoracic echocardiographic exam in presence of PDA. Multivariable logistic regression was used to create a coarctation probability model (CoMOD) including isthmal (D4), transverse arch (D3) diameters, the distance between a left common carotid artery (LCA) and left subclavian artery (LSA), presence/absence of ventricular septal defect (VSD) and bicuspid aortic valve (BAV).
Results
We enrolled 87 neonates (49 male, 56%). 44 patients developed CoA in need of surgical repair. Our index CoMOD showed an AUC = 0.9382, high sensitivity (91%) and specificity (86%) in the prediction of CoA in neonates with prenatal suspicion. We classified neonates with CoMOD > 0 to be at high risk for surgical correction of CoA, with good PPV (86.9%) and NPV (90.9%).
Conclusions
CoMOD > 0 is highly suggestive of the need for CoA corrective surgery in newborns with prenatal suspicion.
Author contributors’
Dr Bartolacelli, Dr Palleri, Dr Balducci, Dr Ragni, conceptualized and designed the study, drafted the initial manuscript, and reviewed and revised the manuscript. Dr Bartolacelli, Dr Palleri, Dr Bonetti, Dr Hasan, Dr Fabi, designed the data collection instruments, collected data, carried out the initial analyses. Dr Bartolacelli, Dr Palleri, Dr Egidy Assenza, Dr Mariucci, Dr Angeli reviewed and revised the manuscript. Professor Gargiulo and Dr Donti conceptualized and designed the study, coordinated and supervised data collection, and critically reviewed the manuscript for important intellectual content. All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work.
Disclosure statement
No potential conflict of interest was reported by the authors.