Abstract
Objective
To evaluate the association between pulmonary hemorrhage and bronchopulmonary dysplasia (BPD) in very low birth weight infants (VLBWIs).
Methods
The study participants were all VLBW newborns admitted from January 1, 2019 to December 31, 2021. The BPD subjects finally included were VLBWIs who survived until the diagnosis was established. This study was divided into pulmonary hemorrhage group (PH group, n = 35) and non-pulmonary hemorrhage group (Non-PH group, n = 190).
Results
By univariate analysis it was found that premature rupture of membranes, tracheal intubation in the delivery room, duration of mechanical ventilation, course of invasive ventilation (≥3 courses), pulmonary surfactant (>1 dose), medically and surgically treated patent ductus arteriosus, grade III-IV RDS, early onset sepsis, BPD and moderate to severe BPD showed significant differences between groups (p < .05). By Multivariate analysis, pulmonary hemorrhage did not increase the risks of BPD and moderate to severe BPD (adjusted OR for BPD = 1.710, 95% CI 0.581–5.039; adjusted OR for moderate to severe BPD = 2.401, 95% CI 0.736–7.834).
Conclusion
It suggests that pulmonary hemorrhage is not associated with the development of BPD and moderate to severe BPD in VLBWIs.
Acknowledgements
The authors would like to thank the parents of the patients for their understanding.
Authors contributions
Jing-jing Pan and Yun-su Zou wrote the manuscript. Jing Wang and Xiao-yu Zhou revised this paper. Mei-ling Tong and Yun-su Zou collected the clinical data. Yang Yang analyzed the data. Rui Cheng and Yang Yang designed this study.
Consent form
All authors listed have read the complete manuscript and have approved submission of the paper.
Disclosure statement
No potential conflict of interest was reported by the author(s).
Data availability statement
The dataset used during this study are available from the corresponding author on reasonable request.