Effect of prophylactic caffeine in the treatment of apnea in very low birth weight infants: a meta-analysis

Abstract

Objective

The purpose of this meta-analysis is to investigate the effect of prophylactic caffeine use in the treatment of apnea and other clinical outcomes in very low birth weight infants.

Methods

We searched PubMed, Embase, Web of Science, Scopus, EBSCO, CNKI, and Cochrane databases for all relevant studies up to May 20, 2022. The meta-analysis was carried out using Stata16.0 and RevMan5.4 software.

Results

Eleven randomized controlled trials were evaluated, including a total of 4375 very low birth weight infants. The results demonstrated that prophylactic caffeine use was linked with a significantly lower probability of AOP (OR 0.31, 95% CI: 0.19–0.49, p < .001), duration of mechanical ventilation and oxygen therapy when compared to the control group. It also reduced the incidence of BPD (OR 0.62, 95% CI: 0.54–0.71, p < .001), PDA (OR 0.49, 95% CI: 0.30–0.80, p = .005) and ROP (OR 0.76, 95% CI: 0.65–0.90, p = .001), without raising the risk of NEC, IVH and death before hospital discharge (p > .05).

Conclusion

This meta-analysis confirmed the beneficial effects of prophylactic caffeine in preventing apnea of prematurity and improving clinical outcomes.

Keywords:

• Apnea of prematurity
• caffeine
• very low birth weight infants
• meta-analysis

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This research was supported by Education and Teaching Reform and the Research Project of Weifang Medical University (Grant No. 2019ZD004)