Pain-related changes in crSO₂ among premature infants undergoing PICC insertion

Abstract

Objective

To evaluate the effectiveness of cerebral regional oxygen saturation (crSO₂) values, measured using near-infrared spectroscopy (NIRS), in assessing pain associated with the peripherally inserted central catheter (PICC) in premature infants.

Methods

NIRS was used to measure the crSO₂ levels of 48 premature infants with gestational age (GA) of < 32 weeks or a birth weight of < 1500 g. Premature infant pain profile (PIPP) scores, vital signs, transcutaneous oxygen tension (TcpO₂), transcutaneous carbon dioxide tension (TcpCO₂), and crSO₂ values were monitored. One-way repeated measure analysis of variance was used to compare heart rate (HR), respiratory rate (RR), blood pressure (BP), peripheral oxygen saturation (SpO₂), TcpO₂, TcpCO₂, and crSO₂ values before (Time 1), during (Time 2), and after (Time 3) PICC insertion. The correlation between the PIPP scores at Time 2 and the fluctuations (values detected at Time 2 minus those at Time 1) of SpO_2, TcpO_2, and crSO₂ were also analyzed.

Results

The PIPP score at Time 2 was significantly higher than those at Times 1 and 3. HR, RR, and BP values increased (p < .05), and SpO₂ and crSO₂ levels decreased at Time 2 (p < .05) compared with those at Time 1. Stratified analysis based on GA revealed significant differences in HR, RR, and crSO₂ values between Times 1 and 2 in infants with a GA of ≥ 32 weeks. In infants with a GA < 32 weeks, significant differences were observed in HR, RR, SpO₂, BP, and crSO₂ values between Times 1 and 2. The fluctuation of the crSO₂ level was strongly correlated with the PIPP score at Time 2 (r = −0.829, p < .001). A weak correlation was observed between the PIPP score at Time 2 and TcpO₂ level fluctuation (r = 0.375, p = .009). No correlation was observed between the PIPP score at Time 2 and SpO₂ level fluctuation (r = 0.242, p = .097).

Conclusion

The fluctuation of crSO₂ levels strongly correlates with PICC procedural pain. Hence, crSO₂ levels measured using NIRS may be used as an indicator for pain assessment in premature infants.

Keywords:

• Pain
• crSO₂
• premature infants
• PICC
• PIPP

Disclosure statement

No potential conflict of interest was reported by the authors.

Data availability statement

The data used in this study are available from the corresponding author upon reasonable request.

Additional information

Funding

This study was supported by the Research Foundation of Southwest Medical University (2019ZQN165), and the Key r&d projects of Sichuan Science and Technology Department (Project number:2019YFS0531-19, 2019YFS0531-15).