Advanced glycation end-products inhibitors isolated from Schisandra grandiflora

Abstract

Free radicals scavenging and advanced glycation end-products (AGEs) inhibitory potentials in crude chloroform extract of Schisandra grandiflora were evaluated. Bioassay-guided isolation of the chloroform extract led to the identification of 24 compounds. Among the isolates, ( ± ) gomisin M₁, arisantetralone C and D, macelignan, saurulignan B and SZ-MO displayed potent-free radical scavenging as well as AGEs inhibitory potentials. This is the first report identifying the presence of AGEs inhibitory activity and assigning AGEs inhibitory activity to these compounds. Therefore, our research finds new application of traditional medicinal plant S. grandiflora having capacity to reduce formation and accumulation of AGEs in diabetes.

Keywords:

• Schisandra grandiflora
• diabetes
• free radical scavenging activity
• advanced glycation end-products inhibitor

Acknowledgement

The authors thank Dr M. LakshmiKantam, Director, CSIR-Indian Institute of Chemical Technology for her constant encouragement. DAK thanks DIICT for awarding SPF under CSC-0111.

Additional information

Funding

This work was financially supported by the grant CSC-0111 from Council of Scientific and Industrial research, New Delhi, India under CSIR-XII FYP network programme.