Analysis of clinical characteristics and prognostic factors of ARDS caused by community-acquired pneumonia in people with different immune status

ABSTRACT

Background

The purpose of this study is to describe the clinical characteristics and prognostic risk factors of acute respiratory distress syndrome (ARDS) caused by community-acquired pneumonia under different immune states.

Methods

The patients were divided into immunocompetent and immunocompromised groups according to their immune status. The basic clinical data of the two groups were collected and statistically analyzed, and the clinical characteristics and prognostic factors of ARDS caused by community-acquired pneumonia under different immune states were summarized.

Results

128 patients with ARDS caused by community-acquired pneumonia were enrolled. The chest High-Resolution Computed Tomography (HRCT) scores of patients with immunosuppression were higher (236.0 ± 55.0 vs. 207.5 ± 49.6, p < 0.05) and the score of APACHE II was higher (17.3 ± 4.8 vs. 15.1 ± 5.4, p < 0.05). The 28-day intensive care unit (ICU) mortality was higher in the immunocompromised group (54.5% vs. 34.7%, p = 0.045). The 28-day in-hospital mortality in the immunocompetent group was mainly related to NLR and the oxygenation index. The 28-day in-hospital mortality in the immunocompromised group was mainly related to LDH and APACHE II.

Conclusion

There are differences in clinical characteristics and mortality of ARDS patients caused by community-acquired pneumonia under different immune states.

KEYWORDS:

• ARDS
• immune status
• community-acquired pneumonia
• clinical characteristics
• prognosis

Acknowledgments

We thank all our colleagues at the Infection Management and Disease Control Department for making this study possible.

Declaration of interest

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Reviewer disclosures

Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.

Availability of data and materials

The datasets generated during the current study are not publicly available to maintain the privacy of the patients, but they are available from the corresponding author on reasonable request.

Author contributions

Zhixin Liang conceived of this study and was responsible for the manuscript. Zhipeng Cheng, Qiang Zhu collected the clinical data, interpreted the results, and wrote the manuscript. Jingyi Chen, Yanan Sun participated in data collection and critical revision of the manuscript. All authors read and approved the final manuscript

Ethical approval and consent to participate

The local institutional review board approved this study. The formal consent is not required in our hospital.

Correction Statement

This article has been republished with minor changes. These changes do not impact the academic content of the article.

Additional information

Funding

This study was supported by the Military Medical Innovation Program of China [16CXZ041].