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Original Article

Sudden hearing loss in chronic hepatitis C patient suffering from Turner syndrome, treated with pegylated interferon and ribavirin

Hipoacusia súbita en un paciente con síndrome de Turner y hepatitis crónica C tratado con interferón pegilado y ribavirina

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Pages 345-350 | Received 09 May 2006, Published online: 07 Jul 2009
 

Abstract

Sudden hearing loss is a very rare complication of interferon–alpha treatment. At this time, hearing loss in patients treated with pegylated interferon and ribavirin has only been described in two reports. We present a case of a 27-year-old patient who was diagnosed with Turner syndrome, treated for hepatitis C with pegylated interferon and ribavirin, and suffered from hearing loss during the 10th week of treatment. Audiometric examination revealed a bilateral sensorineural hearing loss (SNHL). Auditory brainstem response (ABR) measures confirmed the diagnosis. We decided to comply with the patient's request to continue therapy, which only led to slight further deterioration of the patient's hearing ability. However, 18 months after the end of therapy a follow-up audiometric examination disclosed a bilateral SNHL.

Sumario

La hipoacusia súbita es una complicación rara en el tratamiento con interferón alfa. Hasta ahora, la hipoacusia en pacientes tratados con interferón pegilado y ribavirina sólo ha sido descrita en dos reportes. Presentamos un caso de un paciente de 27 años de edad con diagnóstico de Síndrome de Turner, y tratado por hepatitis C con interferón pegilado y ribavirina, y quién sufrió una hipoacusia durante la semana 10 de tratamiento. El examen audiométrico reveló una hipoacusia sensorineural (SNHL) bilateral. Una medición de respuestas auditivas del tallo cerebral (ABR) confirmó el diagnóstico. Decidimos respetar la solicitud del paciente de continuar con la terapia, que llevó a un leve deterioro mayor en la capacidad auditiva del paciente. Sin embargo, 18 meses después del término de la terapia, un estudio audiométrico de seguimiento mostró una hipoacusia sensorineural bilateral (SNHL).

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