Caloric restriction is the only known method of increasing lifespan in laboratory animals. The present study was conducted as part of a larger investigation into the effect of caloric restriction on longevity of rhesus monkeys as a model for human aging. This study focused on the effects of caloric restriction and aging on measures of middle-ear function measured with tympanometry. Peak compensated static acoustic admittance (peak Ytm) tended to be reduced with aging. For tympanometric width (TW), the effect of age was significant with TW increasing with age. Males had a trend of narrower TW than females. A significant age by sex interaction indicated that TW for males stays relatively constant, whereas TW for females increases with age. The equivalent ear canal volume (Vea) was significantly larger in male monkeys than in female monkeys, and marginally larger for the control monkeys than for the caloric restricted monkeys. These results parallel many findings in middle-ear function in aging humans. Longitudinal studies are planned.
Tympanometry in rhesus monkeys: Effects of aging and caloric restriction
2008, Vol. 47, No. 4
,
Pages 209-214
(doi:10.1080/14992020701851882)
Cynthia G. Fowler1†, Kirstin Beach Chiasson2, Dianna Brown Hart3, T. Mark Beasley4, Joseph Kemnitz5 and Richard Weindruch6
1Department of Communicative Disorders, University of Wisconsin-Madison, , USA
2Oregon Institute of Technology, Klamath Falls, USA
3University of Minnesota Medical Center, Fairview, USA
4Department of Biostatistics, University of Alabama at Birmingham, , USA
5Wisconsin National Primate Research Center and Department of Physiology, University of Wisconsin-Madison, , USA
6Department of Medicine, University of Wisconsin-Madison and Wm. S. Middleton Memorial Veteran's Hospital, Madison, USA
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