GC-MS Analysis of β-Carotene Ethenolysis Products and their Synthesis as Potentially Active Vitamin A Analogues

I. Jermacz Institute of Chemistry, University of Bialystok, Al. Pilsudskiego 11/4, 15-443, Bialystok, Poland

J. Maj Institute of Chemistry, University of Bialystok, Al. Pilsudskiego 11/4, 15-443, Bialystok, Poland

J. W. Morzycki Institute of Chemistry, University of Bialystok, Al. Pilsudskiego 11/4, 15-443, Bialystok, Poland

A. Wojtkielewicz Institute of Chemistry, University of Bialystok, Al. Pilsudskiego 11/4, 15-443, Bialystok, Poland

ABSTRACT

β-Carotene ethenolysis under promotion of well-defined ruthenium catalysts were examined as a novel method of synthesis of vitamin A derivatives. Efficient reaction was promoted by the second-generation Hoveyda catalyst. The products of ethenolysis in positions C15-C15′, C11-C12, and C9-C10 were detected, but cleavage of the C11-C12 double bond predominated. Even better regioselectivity at this position was observed for cross−metathesis between β-carotene and functionalized alkenes.

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GC-MS Analysis of β-Carotene Ethenolysis Products and their Synthesis as Potentially Active Vitamin A Analogues

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GC-MS Analysis of β-Carotene Ethenolysis Products and their Synthesis as Potentially Active Vitamin A Analogues

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