In Vitro Interaction of Lithium on Phospholipids in Human Erythrocytes

A. Sankiewicz Department of Electrochemistry, Institute of Chemistry, University of Bialystok, Al. J. Pilsudskiego11/4, 15–443, Bialystok, Poland

E. Gorodkiewicz Department of Electrochemistry, Institute of Chemistry, University of Bialystok, Al. J. Pilsudskiego11/4, 15–443, Bialystok, Poland

Z. Figaszewski Department of Electrochemistry, Institute of Chemistry, University of Bialystok, Al. J. Pilsudskiego11/4, 15–443, Bialystok, Poland; Laboratory of Electrochemical Power Sources, Faculty of Chemistry, University of Warsaw, Pasteur St. 1, 02–093, Warsaw, Poland

ABSTRACT

Lithium salts are used in the treatment of mania and as prophylaxis against manic depressive disorder. The aim of these studies was the in vitro investigation of the effect of lithium on phospholipids of human erythrocyte membranes. Erythrocytes were treated with lithium for 1 h. Phospholipids phosphatidylinositol (PI), phosphatidylserine (PS), phosphatidylethanolamine (PE), and phosphatidylocholine (PC) were separated from erythrocyte ghosts and determined by HPLC. Blood samples from healthy adults were investigated. A very strong decrease in PC content in erythrocyte membranes due to lithium in vitro treatment was found, as well as a statistically significant increase in PI content.

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In Vitro Interaction of Lithium on Phospholipids in Human Erythrocytes

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In Vitro Interaction of Lithium on Phospholipids in Human Erythrocytes

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