![Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5925/TOC-Subject-Sample-2021-Bioscience.jpg"})
Abstract
To evaluate the protective effects of dark soy sauce (DSS) against acrylamide (ACR)-induced neurotoxicity in rats, 60 adult Sprague Dawley female rats were given DSS (0.5 ml/kg body weight/day) before, after, and during ACR treatment (10 mg/kg body weight/day) for 8 weeks in total. Treatment only with ACR resulted in a significant increase in lipid peroxidation level, lactate dehydrogenase, and serum creatine kinase activity, but a significant decrease in superoxide dismutase activity in brain homogenate. Moreover, serum serotonin, corticosterone, 3, 5, 3′-triiodothyronine, and L-thyroxine, thyroid stimulating hormone, estradiol, progesterone, and plasma adrenaline decreased significantly in ACR rats. Treatment with DSS before, during, and after ACR treatment partially antagonized the effects induced by ACR. In conclusion, DSS exhibited a protective action against ACR-induced oxidative stress and biochemical perturbations in rats; and treatment with DSS during ACR exposure was more effective than after or before ACR treatment.
Acknowledgements
Project supported by Universities Science and Technology Research and Development Item of Shanxi Province (No.20051222), Programs for Science and Technology Development of Shanxi Province (No.052011), and the Natural Science Foundation of Fujian Province of China (No.2007J0107).
Declaration of interest: The authors report no conflict of interest. The authors alone are responsible for the content and writing of the paper.