PTPN22 Gene Polymorphisms in Pediatric Systemic Lupus Erythematosus

Abstract

Objective: Pediatric systemic lupus erythematosus (PSLE) is a heterogeneous autoimmune disorder of unknown origin. PTPN22 gene polymorphisms have been associated with SLE in different populations. We investigated the associations of the rs2476601, rs1217414, rs33996649, rs1276457, and rs1310182 SNPs in the PTPN22 gene with PSLE. Materials and methods: 55 PSLE patients and 93 healthy controls were recruited. SNPs were genotyped by the real-time PCR allelic discrimination method. Results: We found that the PTPN22 polymorphisms rs1310182 A allele (p = 0.01, OR = 1.92 95% CI = 1.16–3.18), and rs1310182 AA genotype with (p < 0.001) and rs12760457 TT (p = 0.046) were associated with PSLE. No significant associations were found between other SNPs and PSLE. Conclusions: The PTPN22 rs1310182 A allele and rs1310182 AA genotype were associated with PSLE and may be a possible genetic marker for susceptibility to PSLE. However, further investigation would be required to elucidate the mechanistic role of this association.

Keywords:

• pediatric systemic lupus erythematosus (PSLE)
• PTPN22 polymorphisms
• genetic susceptibility
• Iranian population

Acknowledgments

The authors would like to announce their appreciation to all contributors who have made the achievement of this study.

Disclosure statement

The authors declare that they have no conflicts of interest concerning this article.

Additional information

Funding

Research reported in this publication was supported by Elite Researcher Grant Committee under award number from the National Institute for Medical Research Development (NIMAD) [grant No. 971076], Tehran, Iran.