Unifocal Type-3 Mixed Histiocytosis in a 10-Years Old Child

Abstract

Background

Histiocytoses patients present with highly heterogeneous clinical and histopathological pictures requiring multidisciplinary management. Mixed histiocytosis is a recently described group of syndromes defined by the histological overlap of Langerhans cell histiocytosis and other histiocytic proliferations that include three clinically and prognostically different conditions (i.e., Type-1–3 mixed histiocytosis).

Case report

We describe a 10 year-old boy with unifocal (type-3) mixed histiocytosis – Langerhans cell histiocytosis combined with a lesion with features intermediate between Rosai-Dorfman disease and reticulohistiocytosis. Sixty months after excision, the child is disease free.

Discussion

Cutaneous type-3 mixed histiocytosis (Langerhans cell histiocytosis with Rosai-Dorfman disease/reticulohistiocytosis) may occur in older childhood, be unifocal, and be cured by surgical excision.

Keywords:

• Histiocytosis
• Langerhans cell histiocytosis
• differential diagnosis
• prognosis
• surgery
• cutaneous pathology

Disclosure statement

No potential conflict of interest was reported by the authors.

Ethics approval statement

The study was conducted following local ethical guidelines and the Helsinki declaration.

Patient consent statement

The patient’s informed consent was gathered.

Permission to reproduce material from other sources

N/A.

Data availability statement

Data are fully available upon the author’s request

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.