![Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5925/TOC-Subject-Sample-2021-Bioscience.jpg"})
Abstract
Introduction. Castor and jequirity beans are uncommon causes of poisoning. The more common but less severe castor poisoning is well described, but jequirity bean (Abrus Precatorius) poisoning is rare. The toxicity is attributed to toxalbumins (ricin and abrin) that act by inhibiting protein synthesis. Their use as agents of biological warfare, mechanisms of action, and clinical features of poisoning are summarized. Case Report. A 30-year-old previously healthy female presented with bloody diarrhea and deep coma following ingestion of 3–4 seeds of a plant called ‘ratti.’ Investigations, including an MRI brain scan, showed evidence of acute demyelinating encephalitis. The patient died three days later due to progressive central nervous system depression. Discussion. This is a previously unreported manifestation of jequirity bean poisoning. Demyelination is immune-mediated, andAbrus is a well-known immuno-modulator and stimulator. A possible immunological pathogenic mechanism is hypothesized.