Regional variation in the severity of pesticide exposure outcomes: applications of geographic information systems and spatial scan statistics

Abstract

Introduction: Geographic information systems and spatial scan statistics have been utilized to assess regional clustering of symptomatic pesticide exposures reported to a state Poison Control Center (PCC) during a single year. In the present study, we analyzed five subsequent years of PCC data to test whether there are significant geographic differences in pesticide exposure incidents resulting in serious (moderate, major, and fatal) medical outcomes. Methods: A PCC provided the data on unintentional pesticide exposures for the time period 2001–2005. The geographic location of the caller, the location where the exposure occurred, the exposure route, and the medical outcome were abstracted. Results: There were 273 incidents resulting in moderate effects (n = 261), major effects (n = 10), or fatalities (n = 2). Spatial scan statistics identified a geographic area consisting of two adjacent counties (one urban, one rural), where statistically significant clustering of serious outcomes was observed. The relative risk of moderate, major, and fatal outcomes was 2.0 in this spatial cluster (p = 0.0005). Conclusions: PCC data, geographic information systems, and spatial scan statistics can identify clustering of serious outcomes from human exposure to pesticides. These analyses may be useful for public health officials to target preventive interventions. Further investigation is warranted to understand better the potential explanations for geographical clustering, and to assess whether preventive interventions have an impact on reducing pesticide exposure incidents resulting in serious medical outcomes.

Keywords :

• Epidemiology
• Insecticides
• Pesticide
• Poison Control Centers
• Statistics

Acknowledgments

DS acknowledges the NIH funding that partially supports his epidemiological research activities. He received grant support from NIEHS grant P30 ES00210 (Integrative Health Science Facility Core, Environmental Health Science Center). He has served as an advisor for the Pyrethrum Joint Venture, an organization that includes the manufacturers of pyrethrin insecticides.