An Unusual Skin Exposure to Copper; Clinical and Pharmacokinetic Evaluation

Yedidia Bentur Division of Clinical Pharmacology & Toxicology, Poison Control Center, Department of Pediatrics & The Research Institute, The Hospital for Sick Children Departments of Pediatrics and Pharmacology, University of Toronto, Toronto, Ontario, M5G 1X8

, MD,

Gideon Koren Division of Clinical Pharmacology & Toxicology, Poison Control Center, Department of Pediatrics & The Research Institute, The Hospital for Sick Children Departments of Pediatrics and Pharmacology, University of Toronto, Toronto, Ontario, M5G 1X8

, MD,

Michael McGuigan Division of Clinical Pharmacology & Toxicology, Poison Control Center, Department of Pediatrics & The Research Institute, The Hospital for Sick Children Departments of Pediatrics and Pharmacology, University of Toronto, Toronto, Ontario, M5G 1X8

, MD &

Stephen P. Spielberg Division of Clinical Pharmacology & Toxicology, Poison Control Center, Department of Pediatrics & The Research Institute, The Hospital for Sick Children Departments of Pediatrics and Pharmacology, University of Toronto, Toronto, Ontario, M5G 1X8

, MD, PhD

Abstract

Skin exposure to copper is rare and has been described only with copper sulfate. A case of skin exposure to copper after an explosion of copper azide is presented. The amount of copper absorbed by this route was estimated to be 7.7 mg. Calculated distribution volume was 2.02 1/kg, half-life was 167.4 days and clearance was 0.0058 ml/min/kg. The authors also demonstrated metallic copper to be radiopaque, in contrast to copper salts. It is suggested that copper may be absorbed from the skin even if it is in the metal form. Careful clinical follow up as well as serial determinations of serum copper should guide the need for chelation therapy.

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