A Case of Sotalol Poisoning with Fatal Outcome

D. Perrot Department of Intensive Care Medicine, Department of Clinical Pharmacology, Hôpital Edouard Herriot, 69437, LYON, Cedex 03

B. Bui-Xuan Department of Intensive Care Medicine, Department of Clinical Pharmacology, Hôpital Edouard Herriot, 69437, LYON, Cedex 03

J. Lang Department of Intensive Care Medicine, Department of Clinical Pharmacology, Hôpital Edouard Herriot, 69437, LYON, Cedex 03

Y. Bouffard Department of Intensive Care Medicine, Department of Clinical Pharmacology, Hôpital Edouard Herriot, 69437, LYON, Cedex 03

B. Delafosse Department of Intensive Care Medicine, Department of Clinical Pharmacology, Hôpital Edouard Herriot, 69437, LYON, Cedex 03

G. Faucon Department of Intensive Care Medicine, Department of Clinical Pharmacology, Hôpital Edouard Herriot, 69437, LYON, Cedex 03

J. Motin Department of Intensive Care Medicine, Department of Clinical Pharmacology, Hôpital Edouard Herriot, 69437, LYON, Cedex 03

show all

Abstract

The case of a 58 year old woman who died after ingestion of 14.4 g of sotalol and 50 mg of triazolam is described. Despite medical treatment, intracardiac pacing and hemodialysis, cardiovascular failure persisted and became irreversible. High sotalol concentrations were observed in plasma (65 μg/ml) and in post mortem tissues samples. Tissue to plasma ratios ranged from 2.5 to 6. The high drug concentration found in heart tissue (104.4 μg/g) explains the difficulties experienced in the sotalol poisoning.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

A Case of Sotalol Poisoning with Fatal Outcome

Information for

Open access

Opportunities

Help and information

A Case of Sotalol Poisoning with Fatal Outcome

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature