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Abstract
In this study we assessed the protective effect of topical application of Pothomorphe umbellata extract on ultraviolet B (UVB)-induced skin lesion parameters in hairless mouse epidermis. A single dose of UVB irradiation (0.23 kJ/m2) resulted in a significant decrease in thymine dimer-positive cells and apoptotic sunburn cells, with an increase in p53 and proliferating cell nuclear antigen-positive cells in the epidermis. After 5 weeks (total dose 13.17 kJ/m2) and 15 weeks (total dose 55.51 kJ/m2) of irradiation, P. umbellata treatment inhibited the hyperplasic response and induced an increase in p53-positive cells. These findings suggest that P. umbellata extract affords protection against UVB-induced skin lesions.
Acknowledgments
This work has been supported by Fundação de Amparo a Pesquisa do Estado de São Paulo – FAPESP (doctoral fellowship to Vanessa Vitoriano da Silva (02/13106-7), postdoctoral fellowship to Cristina Dislich Ropke (03/10917-7), project support grant (04/03507-0). We also would like to thank Prof. Paolo Di Mascio for the radiometry measurements.
Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.