Itraconazole-induced thrombocytopenia

Abstract

Itraconazole is one of the systemic treatment options for extensive tinea versicolor. A male patient who developed thrombocytopenia during the treatment of tinea versicolor by itraconazole is reported in this manuscript. He was diagnosed to develop thrombocytopenia on the third day of treatment. In the literature, there are two reports of itraconazole-induced thrombocytopenia both in malignancy patients. One report contained three patients who developed thrombocytopenia as a result of a drug interaction between bortezomib and itraconazole. The other report contained a patient who developed thrombocytopenia following six weeks of treatment with itraconazole. It is hypothesized by the author of this manuscript that this patient’s thrombocytopenia developed as a result of selective bone marrow suppression which is brought about by itraconazole’s effect on megakaryocytes.

Keywords:

• Adverse effect
• itraconazole
• megakaryocyte
• platelet production
• STAT proteins
• thrombopoietin

Declaration of interest

The author reports no conflict of interest and financial support.