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Abstract
Cytoprotector amifostine (AMI) was given in a dose of 50, 100 or 150 mg/kg ip in rats treated with several highly toxic doses of T-2 toxin. The best survival rate (24 h and 7 days after treatment) was obtained with AMI50 (50 mg/kg ip). After T-2 intoxication, a peak in the mean number of gastric lesions (petechiae and ulcerations) was reached on the third day (26.40 ± 6.24). Administration of AMI50 reduced, almost completely, the total number of gastric lesions in rats acutely poisoned by 0.5 LD50 T-2 (1.5 mg/kg sc), starting with day 1 after intoxication (5.60 ± 3.42).
Acknowledgements
This work received partial financial support from the Ministry of Education, Science and Technological Development of the Republic of Serbia, and from the Ministry of Defense of the Republic of Serbia. This work was also supported by long-term development plan UHK and UHHK of the Czech Republic.
Declaration of interest
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.