Mitigating impact of l-carnitine against dimethoate induction of hepatic and testicular genotoxicity in rats: the role of oxidative stress

Abstract

Dimethoate (DM) is a widely used organophosphate insecticide in Egyptian fields with toxic impacts on mammalians. This paper intends to evaluate the role of l-carnitine (LC) on DM-generated hepatic and testicular subchronic genotoxicity. Male rats were partitioned into 4 groups: I: control; II: DM (20 mg/kg b.wt.); III: DM + LC (200 mg/kg b.wt.); IV: LC only. All treatments administered orally twice weekly for 11 weeks. Significant DNA damage, histopathological changes, intense caspase 3 and Bax immune-expression decrease in catalase (CAT); superoxide dismutase (SOD) activities with increase in malondialdehyde (MDA) levels were revealed. Co-treatment of LC with DM alleviated all the above alterations.

Keywords:

• Dimethoate
• genotoxicity
• l-Carnitine
• oxidative stress
• apoptosis

Acknowledgments

The authors would like to express their gratitude to biochemistry, physiology, internal medicine and pathology departments, faculty of veterinary medicine, Kafrelsheikh University, Egypt, for their kind support in this work.

Disclosure statement

No potential conflict of interest was reported by the authors.