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Letters to the Editor

Blood levels of catecholamine metabolites and brain-derived neurotrophic factor in a case of Sydenham's chorea

, , , , , , , , , & show all
Pages 248-251 | Received 06 Jun 2007, Published online: 13 Aug 2009
 

Abstract

We report a case of Sydenham's chorea with neuropsychiatric symptoms who was successfully treated with low-dose risperidone. We also longitudinally investigated serum BDNF levels and plasma levels of catecholamine metabolite in the patient. Serum BDNF levels were increased and plasma levels of HVA and MHPG were decreased according to the recovery from the active phase of the disease. These results suggest that dysfunctions of catecholaminergic neurons and neurotrophic factors might exist in Sydenham's chorea, and the decreasing catecholamine activities in response to risperidone might be associated with the improvement of the disease.

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