The World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Biological Treatment of Bipolar Disorders: Update 2009 on the Treatment of Acute Mania, World Journal of Biological Psychiatry, Informa Healthcare

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The World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Biological Treatment of Bipolar Disorders: Update 2009 on the Treatment of Acute Mania

2009, Vol. 10, No. 2 , Pages 85-116 (doi:10.1080/15622970902823202)

Prof. DrHeinz Grunze¹,² ^†, Eduard Vieta³, Guy M. Goodwin⁴, Charles Bowden⁵, Rasmus W. Licht⁶, Hans-Jürgen Möller², Siegfried Kasper⁷, WFSBP Task Force on Treatment Guidelines for Bipolar Disorders⁸, Prof. DrHeinz Grunze¹,² ^†, Eduard Vieta³, Guy M. Goodwin⁴, Charles Bowden⁵, Rasmus W. Licht⁶, Hans-Jürgen Möller², Siegfried Kasper⁷ and WFSBP Task Force on Treatment Guidelines for Bipolar Disorders⁸

¹Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK

²Department of Psychiatry, Ludwig-Maximilians-University, Munich, Germany

³Bipolar Disorders Programme, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain

⁴Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK

⁵Department of Psychiatry, University of Texas Health Science Center, San Antonio, TX, USA

⁶Mood Disorders Research Unit, Aarhus University Hospital, Risskov, Denmark

⁷Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria

⁸WFSBP Task Force on Treatment Guidelines for Bipolar Disorders

Chairman: Siegfried Kasper (Austria), Co-Chairman: Guy Goodwin (United Kingdom), Co-Chairman: Charles Bowden (USA), Secretary: Heinz Grunze (United Kingdom), WFSBP Past-President: Hans-Jürgen Möller (Germany), Eduard Vieta (Spain); Members: Hagop Akiskal (USA), JoséLuis Ayuso-Gutierrez (Spain), Michael Bauer (Germany), Per Bech (Denmark), Michael Berk (Australia), Istvan Bitter (Hungary), Graham Burrows (Australia), Joseph Calabrese (USA), Giovanni Cassano (Italy), Marcelo Cetkovich-Bakmas (Argentina), John C. Cookson (United Kingdom), I. Nicol Ferrier (United Kingdom),Wagner F. Gattaz (Brazil), Frederik K. Goodwin (USA), Gerhard Heinze (Mexico), Teruhiko Higuchi (Japan), Robert M. Hirschfeld (USA), Cyril Hoeschl (Czech Republik), Edith Holsboer-Trachsler (Switzerland), Kay Redfield Jamison (USA), Cornelius Katona (UK), Martin Keller (USA), E. Kostukova (Russia), Hever Kruger (Peru), Parmanand Kulhara (India), Yves Lecruibier (France), Veronica Larach (Chile), Rasmus W. Licht (Denmark), Odd Lingjaerde (Norway), Henrik Lublin (Denmark), Mario Maj (Italy), Julien Mendlewicz (Belgium), Roberto Miranda Camacho (Mexico), Philip Mitchell (Australia), S. Mosolov (Russia), Stuart Montgomery (United Kingdom), Charles Nemeroff (USA), Willem Nolen (The Netherlands), Eugene S. Paykel (United Kingdom), Robert M. Post (USA), Stanislaw Puzynski (Poland), Zoltan Rihmer (Hungary), Janusz K. Rybakowski (Poland), Per Vestergaard (Denmark), Peter C. Whybrow (USA), Kazuo Yamada (Japan)

^†Correspondence: Institute of Neuroscience, Department of Psychiatry, RVI, Newcastle University, Newcastle upon Tyne, NE1 4LP, UK, +44 191 282 5765, +44 191 222 6162 Heinz.Grunze@ncl.ac.uk

These updated guidelines are based on a first edition that was published in 2003, and have been edited and updated with the available scientific evidence until end of 2008. Their purpose is to supply a systematic overview of all scientific evidence pertaining to the treatment of acute mania in adults. The data used for these guidelines have been extracted from a MEDLINE and EMBASE search, from the clinical trial database clinicaltrials.gov, from recent proceedings of key conferences, and from various national and international treatment guidelines. Their scientific rigor was categorised into six levels of evidence (A–F). As these guidelines are intended for clinical use, the scientific evidence was finally asigned different grades of recommendation to ensure practicability.