Sustained release ocular drug delivery systems for glaucoma therapy

ABSTRACT

Introduction

Glaucoma is a group of progressive optic neuropathies resulting in irreversible blindness. It is associated with an elevation of intraocular pressure (>21 mm Hg) and optic nerve damage. Reduction of the intraocular pressure (IOP) through the administration of ocular hypotensive eye drops is one of the most common therapeutic strategies. Patient adherence to conventional eye drops remains a major obstacle in preventing glaucoma progression. Additional problems emerge from inadequate patient education as well as local and systemic side effects associated with adminstering ocular hypotensive drugs.

Areas covered

Sustained-release drug delivery systems for glaucoma treatment are classified into extraocular systems including wearable ocular surface devices or multi-use (immediate-release) eye formulations (such as aqueous solutions, gels; ocular inserts, contact lenses, periocular rings, or punctual plugs) and intraocular drug delivery systems (such as intraocular implants, and microspheres for supraciliary drug delivery).

Expert opinion

Sustained release platforms for the delivery of ocular hypotensive drugs (small molecules and biologics) may improve patient adherence and prevent vision loss. Such innovations will only be widely adopted when efficacy and safety has been established through large-scale trials. Sustained release drug delivery can improve glaucoma treatment adherence and reverse/prevent vision deterioration. It is expected that these approaches will improve clinical management and prognosis of glaucoma.

KEYWORDS:

• Glaucoma
• IOP
• adherence
• fluctuation in IOP
• sustained-release drug delivery

Article highlights

• Over 55 million people worldwide are affected by primary open-angle glaucoma (POAG) which if untreated would lead to irreversible sight loss

• Ocular hypotensive drugs administered as eye drops are often associated with therapy failure due to systemic and local side effects as well as poor adherence, especially in the elderly population

• Extraocular and intraocular sustained drug delivery systems for glaucoma treatment could provide improved therapies with better patient adherence

• These approaches will improve clinical management and prognosis of glaucoma and subsequently the lives of many patients.

Declaration of interest

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Reviewer disclosures

Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.

Additional information

Funding

This paper was not funded.