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Funding for this work was provided by Merck & Co., Inc. Kenilworth, New Jersey, USA. All authors are currently employed by Merck & Co., Inc. Kenilworth, New Jersey, USA and own stock/stock options in the company. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
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