Cu(im)₂-derived Cu@N–C catalyst for one-pot synthesis of 2-substituted indoles via domino Sonogashira coupling-cyclization reactions

ABSTRACT

Cu(im)₂-derived Cu@N–C(600) catalyst has been efficiently utilized for the preparation of N-tosyl(H)−2-substituted indoles through one-pot domino Sonogashira coupling-cyclization reactions between N-tosyl(acetyl)−2-iodo anilines and aryl acetylenes. The catalytic system was heterogeneous and showed excellent functional group compatibility and could be performed well, affording the corresponding coupling products in good to excellent yields.

GRAPHICAL ABSTRACT

KEYWORDS:

• MOF-derived catalyst
• Cu@N–C
• Sonogashira coupling-cyclization
• 2-substituted indole
• heterogeneous catalyst

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was financial supported by the Natural Science Foundation of Hunan Province (2021JJ30290), National Natural Science Foundation of China (NSFC, No. 21868032) and the construct program of applied characteristic discipline in Hunan University of Science and Engineering.