Reference Centiles to Monitor the 6-minute-walk Test in Ambulant Children with Cerebral Palsy and Identification of Effects after Rehabilitation Utilizing Whole-body Vibration

Kyriakos Martakisa Medical Faculty and University Hospital, Centre of Prevention and Rehabilitation, Cologne, Germany;b Medical Faculty and University Hospital, Department of Pediatrics, University of Cologne, Cologne, Germany;c Faculty of Health, Medicine and Life Sciences, Department of International Health, Care and Public Health Research Institute, School CAPHRI, Maastricht University, Maastricht, The Netherlands;d Department of Pediatric Neurology, Social Pediatrics and Epileptology, Justus-Liebig-University Giessen and UKGM, Giessen, GermanyCorrespondence[email protected]

https://orcid.org/0000-0003-3982-0914 View further author information

Christina Starkb Medical Faculty and University Hospital, Department of Pediatrics, University of Cologne, Cologne, Germany;e Cologne Centre for Musculoskeletal Biomechanics (CCMB), University of Cologne, Cologne, Germany

https://orcid.org/0000-0003-4247-0679 View further author information

Mirko Rehbergb Medical Faculty and University Hospital, Department of Pediatrics, University of Cologne, Cologne, Germany;f Centre for Rare Skeletal Diseases in Childhood, University of Cologne, Cologne, GermanyView further author information

Oliver Semlerb Medical Faculty and University Hospital, Department of Pediatrics, University of Cologne, Cologne, Germany;f Centre for Rare Skeletal Diseases in Childhood, University of Cologne, Cologne, GermanyView further author information

Ibrahim Durana Medical Faculty and University Hospital, Centre of Prevention and Rehabilitation, Cologne, Germany

https://orcid.org/0000-0003-4044-8822 View further author information

Eckhard Schoenaua Medical Faculty and University Hospital, Centre of Prevention and Rehabilitation, Cologne, Germany;b Medical Faculty and University Hospital, Department of Pediatrics, University of Cologne, Cologne, Germany;e Cologne Centre for Musculoskeletal Biomechanics (CCMB), University of Cologne, Cologne, GermanyView further author information

ABSTRACT

Background: Children with cerebral palsy present age-driven development in gross motor skills and walking capacity.

Aims: To precisely monitor the 6-minute walk test (6MWT) in children with CP, GMFCS levels 1 and 2 over 6 months and to assess the effect of a 6-month rehabilitation program including whole-body vibration.

Methods: Retrospective analysis of data of 157 children with CP who received standardized rehabilitation (DRKS00011331). 6MWT was assessed at the start (M0) and end of the training (M6), as well as at a 6-month follow-up (M12). Centiles were created using the lambda-mu-sigma (LMS) method.

Results: We created 6MWT percentiles using data of all 157 children (M0 data). A medium treatment effect size (Cohen’s d = 0.69) was found (M6 and M12 data).

Conclusions: The generated centiles may help monitor 6MWT changes over 6 months. Combining WBV and conventional physiotherapy can significantly improve 6MWT in children with CP.

Abbreviations: 6MWT: 6-Minute Walk Test; CP: Cerebral palsy; ES: effect size; GMFCS: Gross Motor Function Classification System; GMFM-66: Gross Motor Function Measure 66; LOESS: locally weighted scatterplot smoothing; LMS: lambda-mu-sigma; MCID: minimal clinical important difference; SD: standard deviation; SRM: standardized response mean; WBV: whole-body vibration.

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Acknowledgments

We thank the physical therapists at the UniReha GmbH, Centre of Prevention and Rehabilitation of the University of Cologne for their dedicated and qualitative work. We acknowledge Ida Alperstedt and Angelika Stabrey for database management.

Disclosure Statement

ID is working at the Centre of Prevention and Rehabilitation of the University of Cologne and ES is directing the centre. No further competing interests to declare.

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Reference Centiles to Monitor the 6-minute-walk Test in Ambulant Children with Cerebral Palsy and Identification of Effects after Rehabilitation Utilizing Whole-body Vibration

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Reference Centiles to Monitor the 6-minute-walk Test in Ambulant Children with Cerebral Palsy and Identification of Effects after Rehabilitation Utilizing Whole-body Vibration

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