The impact of endometriosis on early embryo morphokinetics: a case-control study

ABSTRACT

The aim of this study was to evaluate the possible effects of endometriosis on early embryo development, by comparing the morphokinetic development of embryos obtained from women with clinically confirmed endometriosis with the ones obtained from tubal factor infertility cases. A total of 82 cycles/patients including 53 cycles with endometriosis and 29 cycles with tubal factor infertility were evaluated. A total of 439 embryos were scored for embryo morphokinetics. Age, body mass index, fertilization rates were similar within the groups. However, the number of previous ART trials was found to be higher (p < 0.05) in the study group. Also, the number of retrieved oocytes and M2 oocytes were found to be significantly lower in patients with endometriosis (p < 0.01). The duration of the first cell cycle (ECC1) and S2 (the time between t3 and t4) displayed significant distortions compared with embryos in the control group. All other analyzed early morphokinetic parameters (t2, t3, t4, t5, t6, t7, t8) and duration of events (VP, cc2a, ECC2, ECC3, S3) showed similar values between study and control groups, respectively. In the light of these findings, it is apparent that endometriosis predominantly affects the duration of the early morphokinetic events and cell cycles.

KEYWORDS:

• Endometriosis
• embryo morphokinetic
• ICSI

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Notes on contributors

Fazilet Kubra Boynukalin

Fazilet Kubra Boynukalin Substantial contributions to design, acquisition, analysis and interpretation of data, and drafting the article: FKB, MS, MG; critical revision of manuscript and approval of final version of the manuscript: FKB, MS, MG, OC, NF, MB.