Synthesis and Characterization of Rosiglitazone Loaded Magnetic Nanopolymer

ABSTRACT

The delivery of thiazolidine-2,4-dione therapies directly to the site would ultimately allow higher concentrations of the drug to be delivered and prolong circulation time in vivo to enhance the therapeutic outcome of this drug. Therefore, we sought to design magnetic based polymeric nanoparticles for the site directed delivery of rosiglitazone. We have synthesized Fe₃O₄ nanoparticles with an average size of 30 ± 2.5 nm and were well characterized by transmission electron microscopy (TEM), quasi elastic light scattering (QELS), and UV-Visible spectroscopic techniques. These Fe₃O₄ nanoparticles (NPs) were used to prepare rosiglitazone loaded magnetic polymeric nanoparticles (RMN) with an average size of 250 ± 5 nm. Fourier transform infrared (FT-IR) spectroscopy showed the encapsulation of rosiglitazone on the surface of the polymer matrix. The encapsulation of the Fe₃O₄ NPs on the surface of the polymer was confirmed by elemental analysis. We studied the drug loading efficiency of gelatin polymeric systems of various molecular weights. Our findings revealed that the molecular weight of the polymer plays a crucial role in the capacity of the drug loading on the polymer surface. Using a constant amount of polymer and Fe₃O₄ NPs, gelatin at lower molecule weights showed higher loading efficiencies for the drug on their surfaces.

KEYWORDS:

• antidiabetic
• magnetite NPs
• TZDs

Acknowledgments

Authors are thankful to the University Grant Commission (UGC) and Department of Science & Technology (DST), India for their financial support.