Microbial stars: shedding light on gut microbes’ role in insulin resistance and innovative diabetes therapies

ABSTRACT

The role of gut microbiota in insulin resistance (IR), Metabolic Syndrome (MetS), and Type 2 Diabetes Mellitus (T2DM) is rapidly gaining recognition. However, the mechanisms and implications of gut bacteria in these conditions remain enigmatic. This commentary not only highlights the findings of a recent multi-omics study by Takeuchi et al. but also offers a unique perspective by integrating personal opinions and insights. The discussion revolves around the intricate connection between gut microbes and IR, suggesting novel therapeutic potential in targeting gut microbial carbohydrate metabolism for improved IR management and metabolic health.

KEYWORDS:

• Gut microbes
• insulin resistance
• metabolic syndrome
• type 2 diabetes mellitus
• therapies

Disclosure statement

No potential conflict of interest was reported by the author.

Author contributions

Jinwei Zhang: Writing – original draft; Writing – review & editing.

Additional information

Funding

This work was supported by The Royal Society UK (Grant no. IEC\NSFC\201094).