Ecological insights into hematopoiesis regulation: unraveling the influence of gut microbiota

ABSTRACT

The gut microbiota constitutes a vast ecological system within the human body, forming a mutually interdependent entity with the host. In recent years, advancements in molecular biology technologies have provided a clearer understanding of the role of the gut microbiota. They not only influence the local immune status and metabolic functions of the host’s intestinal tract but also impact the functional transformation of hematopoietic stem cells (HSCs) through the gut-blood axis. In this review, we will discuss the role of the gut microbiota in influencing hematopoiesis. We analyze the interactions between HSCs and other cellular components, with a particular emphasis on the direct functional regulation of HSCs by the gut microbiota and their indirect influence through cellular components in the bone marrow microenvironment. Additionally, we propose potential control targets for signaling pathways triggered by the gut microbiota to regulate hematopoietic function, filling crucial knowledge gaps in the development of this research field.

KEYWORDS:

• Hematopoietic stem cell
• gut microbiota
• bone marrow niche

Disclosure statement

No potential conflict of interest was reported by the author(s). Figure 1 and Figure 3 were created by Figdraw (www.figdraw.com).

Availability of data and materials

Materials described in the manuscript will be freely available to any scientist wishing to use them for noncommercial purposes, without breaching participant confidentiality.

Consent for publication

All authors have reviewed the final version of the manuscript and approved it for publication.

Additional information

Funding

This work was supported by the National Key R&D Program of China (2016YFC1303804).