Phosphoneurofilament heavy chain and vascular endothelial growth factor as cerebrospinal fluid biomarkers for ALS

Margarida GonçalvesInstituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal,

Mamede De CarvalhoHospital de Santa Maria, Centro Hospitalar Lisboa-Norte, Lisbon, Portugal, ;Instituto de Medicina Molecular, Faculty of Medicine, University of Lisbon, Portugal, and

Cristina PeixotoInstituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal, ;Instituto de Biologia Experimental e Tecnológica, Oeiras, Portugal

Paula AlvesInstituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal, ;Hospital de Santa Maria, Centro Hospitalar Lisboa-Norte, Lisbon, Portugal, ;Instituto de Medicina Molecular, Faculty of Medicine, University of Lisbon, Portugal, and ;Instituto de Biologia Experimental e Tecnológica, Oeiras, Portugal

Carmo BarretoInstituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal, ;Instituto de Biologia Experimental e Tecnológica, Oeiras, Portugal

Abel OlivaInstituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal, ;Instituto de Biologia Experimental e Tecnológica, Oeiras, Portugal

Susana PintoInstituto de Medicina Molecular, Faculty of Medicine, University of Lisbon, Portugal, and

Ana Laborinho-ProntoInstituto de Medicina Molecular, Faculty of Medicine, University of Lisbon, Portugal, and

Marta GromichoInstituto de Medicina Molecular, Faculty of Medicine, University of Lisbon, Portugal, and

Júlia CostaInstituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal, Correspondence[email protected]

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Acknowledgements

We wish to thank the participants in this study. This work was supported by EU JPND project SOPHIA, Fundação para a Ciência e a Tecnologia (FCT) [JPND/0003/2011], Portugal; Euronanomed 2 ERA-NET project GlioEx, FCT [ENMed/0001/2013]; iNOVA4Health, UI FCT/Ministério da Educação e Ciência [UID/Multi/04462/2013].

Declaration of interest

The authors report no conflicts of interest.

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Phosphoneurofilament heavy chain and vascular endothelial growth factor as cerebrospinal fluid biomarkers for ALS

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