Theme 7 Pre-clinical therapeutic strategies

Acknowledgments:

This work has been supported by NIH-RO1NS085161.

Acknowledgments:

S.T is supported by an International Postgraduate Research Scholarship, awarded by Deakin University (Australia) and a Greek Scholarship for doctoral studies abroad, awarded by the Onassis Foundation.

Acknowledgments:

This work was support by the Giumelli Foundation and the Ian Potter Foundation.

Acknowledgments:

This study was supported by the Giumelli Foundation and the Ian Potter Foundation.

Acknowledgments:

We acknowledge the Parry Foundation and Team Spencer at Muscular Dystrophy Western Australia for project funding.

Acknowledgments:

LiveLikeLou Center for ALS Research at the University of Pittsburgh Brain Institute, Robert Packard Center for ALS Research, NIH NINDS, NIH NIA (R01NS05756, R21NS098379). A generous grant from Barbara McCormick, University of Pittsburgh Center for Protein Conformational Diseases.

Acknowledgments:

Funded by NHMRC.

Acknowledgments:

We acknowledge the Motor Neurone Disease Research Institute of Australia (Betty Laidlaw MND Grant, Jenny Barr Smith Research Grant, Beryl Bayley Postdoctoral Fellowship), FightMND, Sigrid Juselius Foundation, NHMRC, ARC, and the Victorian Brain Bank Network for supporting our research.

Acknowledgments:

The authors thank the Region Centre-Val de Loire, the program ARD2020 Biomédicaments, and the French Ministry of Higher Education and Research as part of the Investissements d’Avenir program: LabEx MAbImprove ANR-10-LABX-53-01.

Acknowledgments:

Funding: MemoLife Labex PhD fellowship to SEVA, Association Nationale de la Recherche et de la Technologie (Cifre/ANRT n° 2017/0488) to ML, BrainEver, HomeoSign ERC -2013-AdG n°339379. Competing interests: A.P and K.L.M. are co-founders and hold shares in a company developing HPs for therapeutic use.

Acknowledgments:

Funding: FightMND Translational Research Grant.

Acknowledgments:

This work was funded by the Stafford Fox Medical Research Foundation and the National Health and Medical Research grant (APP1138033; APP1104295) to FS and BT. AA is a recipient of the Bethlehem Griffiths Research Foundation Scholarship. NP is a recipient of Bill Gole Fellowship from the MND research institute of Australia (MNDRIA).

Acknowledgments:

Funding provided by NHMRC from Project Grant 1124005 and RD Wright Career Development Fellowship 1140386, the Ross Maclean Fellowship for MND Research, and the Brazil Family Program for Neurology.

Acknowledgments:

I would like to thank the Ministry of Higher Education and Scientific Research in Iraq for funding the project. Also, much appreciated to my supervisors who support and guide me throughout the project.

Acknowledgments:

Funding for this study was provided by NIH from grants 1R01NS078214 and 1R01AG051470 and donations for ALS research. The authors declare no conflicts of interest.

Acknowledgments:

Funding for this work was from NH&MRC Grant APP1104299 (Turner, Rogers), and MNDRIA GIA Charcot Grant 1848 (Rogers).

Acknowledgments:

University of Helsinki, Academy of Finland, US Department of Defence, European Research Council.

Acknowledgments:

Funding for this study was provided by NHMRC from Project Grant 1124005 and RD Wright Career Development Fellowship 1140386, the Ross Maclean Fellowship for MND Research, and the Brazil Family Program for Neurology.

Acknowledgments:

This work was supported by the Motor Neuron Disease Research Institute of Australia (MNDRIA; GIA 1827), the National Health and Medical Research Council of Australia (APP1146750), Dementia Teams Grant (1095215), The Snow Foundation and MQ Safety Net Scheme.

Acknowledgments:

This work was supported by FWO-Vlaanderen, the Thierry Latran Foundation, the Muscular Dystrophy Association (MDA, 577668) and the ALS Liga.

Acknowledgments:

AriSLA (HyperALS) and AFM

Acknowledgments:

This work was supported by: AriSLA through HyperALS project (A.F.; J.P. L.; E.F.); AFM-Telethon project n. 2018; AFM-Telethon project n. 21021 (J.P.L.; A.F.).

This work is dedicated to the memory of our dear mentor and friend Maria Teresa Carrì.

Acknowledgments:

We thank fibroblast donors to Johns Hopkins IRB protocols NA_00021979 and NA_00033726.

We thank Neuro-Sys (SAS) for performing the rat MN experiment.

Studies were funded by Clene Nanomedicine, Inc.

Acknowledgments:

We would like to thank Professor J.P Taylor for providing the original mVCP and wtVCP mice. We are grateful to Brain Research UK for support. This study was partly funded by Orphazyme ApS.

Acknowledgments:

This work was supported by Italian Ministry of University and Research [PRIN 2015] to C.L.; by the National Institute of Health [R01 NS098328 (NINDS)] to Heike Wulff. Cristina Limatola is fellow of the Synanet Network (Twinning Project H2020).

Acknowledgments:

This work was supported by Institut Pasteur de Montevideo – FOCEM Mercosur (COF 03/11), Agencia Nacional de Investigación e Innovación (ANII), Programa de Desarrollo de las Ciencias Básicas (PEDECIBA), Sistema Nacional de Investigadores (SNI).

Acknowledgments:

This work was supported by CABBIO, CSIC, FOCEM, ANII, CAP, PEDECIBA, PROINBIO and Institut Pasteur de Montevideo.

Acknowledgments:

This work was supported by Institut Pasteur de Montevideo – FOCEM Mercosur (COF 03/11), Agencia Nacional de Investigación e Innovación (ANII), Programa de Desarrollo de las Ciencias Básicas (PEDECIBA), Sistema Nacional de Investigadores (SNI) and ABScience.

Acknowledgments:

We would like to thank the patients who donated their skin biopsies for this study

Acknowledgments:

This work was funded by Pharnext. All authors except Noëlle Callizot are employee of Pharnext. RH, NC, SN and DC are cited in patents held by Pharnext.

Acknowledgments:

All authors are employees of Orion Pharma. The study was sponsored by Orion Pharma.