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Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration Volume 23, 2022 - Issue 7-8
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ALS Untangled

ALSUntangled #64: butyrates

Yuyao Sun1 Neurology Department, Duke University, Durham, NC, USAView further author information
,
Richard Bedlack1 Neurology Department, Duke University, Durham, NC, USACorrespondence[email protected]
View further author information
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Carmel Armon2 Department of Neurology, Loma Linda University, Loma Linda, CA, USAView further author information
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Morgan Beauchamp3 Undergraduate, North Carolina State University, Raleigh, NC, USAView further author information
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Tulio Bertorini4 Neurology Department, University of Tennessee Health Science Center, Memphis, TN, USAView further author information
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Robert Bowser5 Department of Neurology, Barrow Neurological Institute, Phoenix, AZ, USAORCID Iconhttps://orcid.org/0000-0001-5404-7259View further author information
ORCID Icon,
Mark Bromberg6 Department of Neurology, University of Utah, Salt Lake City, UT, USAView further author information
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James Caress7 Department of Neurology, Baptist Medical Center, Winston Salem, NC, USAView further author information
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Gregory Carter8 Department of Rehabilitation, Elson S. Floyd College of Medicine, Spokane, WA, USAView further author information
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Jesse Crayle9 Neurology Department, Washington University, St. Louis, MO, USAView further author information
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Merit E. Cudkowicz10 Neurology Department, Mass General Brigham Inc, Boston, MA, USAView further author information
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Jonathan D. Glass11 Neurology Department, Emory University, Atlanta, GA, USAView further author information
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Carlayne Jackson12 Department of Neurology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USAView further author information
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Isaac Lund13 Student, Green Hope High School, Cary, NC, USAView further author information
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Sarah Martin14 Physical Therapy Program, Duke University, Durham, NC, USAView further author information
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Sabrina Paganoni10 Neurology Department, Mass General Brigham Inc, Boston, MA, USAView further author information
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Gary Pattee15 Department of Neurology, Nebraska Medical Center, Omaha, NE, USAView further author information
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Dylan Ratner16 Student, Longmeadow High School, Longmeadow, MA, USAView further author information
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Kristiana Salmon17 Department of Neurology, Montreal Neurological Institute, MontrealCanadaView further author information
&
Paul Wicks18 Independent Consultant, UKORCID Iconhttps://orcid.org/0000-0002-2293-9284View further author information
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Pages 638-643 | Received 30 Dec 2021, Accepted 15 Feb 2022, Published online: 28 Feb 2022
 
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Abstract

ALSUntangled reviews alternative and off-label treatments for people living with amyotrophic lateral sclerosis (PALS). Here we review butyrate and its different chemical forms (butyrates). Butyrates have plausible mechanisms for slowing ALS progression and positive pre-clinical studies. One trial suggests that sodium phenylbutyrate (NaPB) in combination with Tauroursodeoxycholic acid (TUDCA) can slow ALS progression and prolong survival, but the specific contribution of NaPB toward this effect is unclear. Butyrates appear reasonably safe for use in humans. Based on the above information, we support a trial of a butyrate in PALS, but we cannot yet recommend one as a treatment.

Declaration of interest

Richard Bedlack has research support from ALSA, Orion, MediciNova, and the Healey Center, and consulting support from AB Science, Alexion, ALSA, Amylyx, Biogen, Black Swan, Brainstorm Cell, Corcept, Cytokinetics, GenieUs, Guidepoint, ITF Pharma, Mallinkrodt, New Biotic, Orphazyme, Shinkei, and Woolsey Pharma.

Additional information

Funding

ALSUntangled is sponsored by the Amyotrophic Lateral Sclerosis Association.

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