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ALS Untangled

ALSUntangled #70: caffeine

Jessica Hatch1 Medical College of Georgia at Augusta University, Augusta, GA, USA

Paul Barkhaus2 Department of Neurology, Medical College of Wisconsin, Milwaukee, WI, USA

Benjamin Barnes3 Department of Neurology, Medical College of Georgia, Augusta, GA, USA

Morgan Beauchamp4 Neurosciences Clinical Trials Unit, UNC, Chapel Hill, NC, USA

Michael Benatar5 Department of Neurology, University of Miami, Miami, FL, USA

Tulio Bertorini6 Neurology Department, University of Tennessee Health Science Center, Memphis, TN, USA

Robert Bowser7 Department of Neurology, Barrow Neurological Institute, Phoenix, AZ, USA

Mark Bromberg8 Department of Neurology, University of Utah, Salt Lake City, UT, USA

Andrew Brown5 Department of Neurology, University of Miami, Miami, FL, USA

Javier Mascias Cadavid9 ALS Department, Hospital Carlos III-La Paz, Madrid, Spain

Gregory T. Carter10 Department of Rehabilitation, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA

Nicholas Cole11 Motor Neurone Disease Association, Northampton, UK

Jesse Crayle12 Department of Neurology, Washington University, St. Louis, MO, USA

Mazen Dimachkie13 Department of Neurology, University of Kansas, Kansas City, KS, USA

David Ennist14 Origent Data Sciences, Inc, Vienna, VA, USA

Eva Feldman15 Department of Neurology, University of Michigan, Ann Arbor, MI, USA

Timothy Fullam16 Department of Neurology, University of Texas, San Antonio, TX, USA

Terry Heiman-Patterson17 Department of Neurology, Temple Health, Philadelphia, PA, USA

Sartaj Jhooty18 University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

Todd Levine19 Bob Bove Neuroscience Institute, Scottsdale, AZ, USA

Xiaoyan Li20 Department of Neurology, Duke University, Durham, NC, USA

Isaac Lund21 Green Hope High School, Cary, NC, USA

Elise Mallon22 Duke University, Durham, NC, USA

Nicholas Maragakis23 Department of Neurology, Johns Hopkins, Baltimore, MD, USA

Christopher McDermott24 Department of Neuroscience, University of Sheffield, Sheffield, UK

https://orcid.org/0000-0002-1269-9053

Gary Pattee25 Department of Neurology, University of Nebraska Medical Center, Omaha, NE, USA

Kaitlyn Pierce26 Department of Neuroscience, University of North Carolina, Chapel Hill, NC, USA

Dylan Ratner27 Tulane University, New Orleans, LA, USA

Kim Staats28 Staats Life Consulting, Los Angeles, CA, USA

Paul Wicks29 Independent Consultant, Lichfield, UK

https://orcid.org/0000-0002-2293-9284

Martina Wiedau30 Department of Neurology, University of California, Los Angeles, CA, USA

Richard Bedlack20 Department of Neurology, Duke University, Durham, NC, USACorrespondence[email protected] [email protected]

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Abstract

ALSUntangled reviews alternative and off-label treatments for people living with amyotrophic lateral sclerosis (PALS). Here, we review caffeine which has plausible mechanisms for slowing ALS progression. However, pre-clinical studies are contradictory, and a large case series showed no relationship between caffeine intake and ALS progression rate. While low doses of caffeine are safe and inexpensive, higher doses can cause serious side effects. At this time, we cannot endorse caffeine as a treatment to slow ALS progression.

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Declaration of interest

The authors of this paper report no relevant disclosures or conflicts. ALSUntangled is supported by the ALS Association under Grant Number 23-SI-622. Drs. Bedlack and Li receive salary support from this grant.

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ALSUntangled #70: caffeine

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