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ALS Untangled

ALSUntangled #72: Insulin

Andrew Brown1 Department of Neurology, University of Miami, Miami, FL, USA

Carmel Armon2 Department of Neurology, Loma Linda University Health, Loma Linda, CA, USA

Paul Barkhaus3 Department of Neurology, Medical College of Wisconsin, Milwaukee, WI, USA

https://orcid.org/0000-0001-8268-8643

Morgan Beauchamp4 UNC Health, UNC, Chapel Hill, NC, USA

Tulio Bertorini5 Neurology Department, University of Tennessee Health Science Center, Memphis, TN, USA

Mark Bromberg6 Department of Neurology, University of Utah, Salt Lake City, UT, USA

Javier Mascias Cadavid7 ALS Department, Hospital Carlos III-La Paz, Madrid, Spain

Gregory T. Carter8 Department of Rehabilitation, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA

Jesse Crayle9 Department of Neurology, St. Louis, MO, USA

Eva L. Feldman10 Department of Neurology, University of Michigan, Ann Arbor, MI, USA

Terry Heiman-Patterson11 Department of Neurology, Temple Health, Philadelphia, PA, USA

Sartaj Jhooty12 University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

Alexandra Linares13 Medical School, Duke University, Durham, NC, USA

Xiaoyan Li14 Department of Neurology, Duke University, Durham, NC, USA

Elise Mallon15 Undergraduate, Duke University, Durham, NC, USA

Christopher Mcdermott16 Department of Neuroscience, University of Sheffield, Sheffield, South Yorkshire, UK

https://orcid.org/0000-0002-1269-9053

Tasnim Mushannen14 Department of Neurology, Duke University, Durham, NC, USA

George Nathaniel15 Undergraduate, Duke University, Durham, NC, USA

Gary Pattee17 Department of Neurology, University of Nebraska Medical Center, Omaha, NE, USA

Kaitlyn Pierce18 Department of Neuroscience, University of North Carolina, Chapel Hill, NC, USA

Dylan Ratner19 Undergraduate, Tulane University, New Orleans, LA, USA

Lenka Slactova20 Institute of Biology and Medical Genetics, Charles University, Prague, Czech Republic, and

Paul Wicks21 Independent Consultant, Lichfield, England, UK

https://orcid.org/0000-0002-2293-9284

Richard Bedlack14 Department of Neurology, Duke University, Durham, NC, USACorrespondence[email protected]

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Abstract

ALSUntangled reviews alternative and off-label treatments for people living with amyotrophic lateral sclerosis (PALS). Here we review insulin, which has at least one plausible mechanism for slowing ALS progression. However, pre-clinical studies are limited and there have been no trials in PALS yet. Insulin use in patients without a metabolic need may cause very serious and potentially lethal side effects. While further studies to evaluate potential benefits may be warranted, at this time we cannot endorse insulin treatment to slow ALS progression.

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Correction Statement

This article was originally published with errors, which have now been corrected in the online version. Please see Correction (http://dx.doi.org/10.1080/21678421.2024.2341556)

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ALSUntangled #72: Insulin

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ALSUntangled #72: Insulin

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