Place of magistral preparations to continue the treatment if the drug is commercially stopped worldwide? A case report of a 10-year-old child with subacute sclerosing panencephalitis (SSPE) requiring inosiplex

ABSTRACT

Subacute sclerosing panencephalitis (SSPE) is a late-onset and fatal viral disease caused by persistent infection of the central nervous system by measles virus (MeV). We present the case of a 10-year-old child from South Asia affected by SSPE, stabilized with a combination of intrathecal interferon-α2b (INF-α2b) injections and oral inosiplex and how we continued the treatment when inosiplex was commercially stopped worldwide.

KEYWORDS:

• Inosiplex
• inosine pranobex
• speciality commercially stopped
• magistral preparation
• subacute sclerosing panencephalitis (SSPE)

Disclosure statement

No potential conflict of interest was reported by the author(s).

Authors contributions

Renan Le Cras and Roseline Mazet wrote and prepared the original draft. Fanny Dubois-Teklali and Cécile Sabourdy: diagnosis, neuroradiological evaluations of the patient. All authors contributed to the draft of the manuscript and they all read and agreed to the published version of the manuscript. Thanks to Paul Granger for his help in reading the MRI images.

Additional information

Funding

This research was partially funded by LabEx ARCANE, ANR-11-LABX-0003-01.