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ABSTRACT
The coronavirus disease 2019 (COVID-19) has caused enormous health risks and global economic disruption. This disease is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 nucleocapsid protein is a structural protein involved in viral replication and assembly. There is accumulating evidence indicating that the nucleocapsid protein is multi-functional, playing a key role in the pathogenesis of COVID-19 and antiviral immunity against SARS-CoV-2. Here, we summarize its potential application in the prevention of COVID-19, which is based on its role in inflammation, cell death, antiviral innate immunity, and antiviral adaptive immunity.
Disclosure statement
No potential conflict of interest was reported by the author(s).
Additional information
Funding
This work was supported by R&D Program of Guangzhou Laboratory (SRPG22-006), College Students’ Innovative Entrepreneurial Training Plan Program (202210487079) and Huazhong University of Science and Technology, HUST Academic Frontier Youth Team (2018QYTD10).